High on Life Walkthrough: Complete Guide & Tips

Blogs rtdfsg 02 Jul , 2026 0

Introduction

If you picked up this high on life walkthrough, you’re likely excited, curious, or maybe stuck on a hilarious, chaotic moment in the game. High on Life blends sharp writing, strange characters, and inventive gunplay into a unique adventure. This guide is an easy-to-follow, step-by-step companion that covers main missions, side quests, weapons, boss fights, collectibles, and smart tips to make your run smoother. Whether you’re a completionist hunting every collectible or a speedrunner after the best route, this High on Life guide delivers practical strategies and clear explanations.

Getting Started: Basics and Best Early Tips

Before diving into the meat of the walkthrough, get the basics right. The opening hours of High on Life are about learning movement, mastering gun mechanics, and meeting your talking-weapon companions. Prioritize these early tips:

Experiment with every weapon you find. High on Life weapons each offer distinct abilities — shotguns, rifles, and comedic, sentient guns with active skills.
Upgrade smart: spend currency on utility upgrades first, like ammo upgrades or ability cooldown reductions. This makes later High on Life boss fights more manageable.
Explore the map. The game rewards exploration with ammo, currency, and hidden collectibles. Use the in-game map and mark areas to revisit.
Talk to characters. NPCs offer both humor and clues. Some side quests unlock only after talking to the right characters at the right time.

These foundational tips set the tone for a smooth playthrough. Keep them in mind as you follow the mission-by-mission walkthrough below.

Walkthrough Part 1: Opening Missions and First Planet

The first planet functions as your tutorial and introduction to the world. Use this section to learn traversal and basic combat. Steps to follow:

Complete the opening mission to unlock your main weapons and meet key allies. Follow mission markers and listen to dialogue for procedural hints.
Collect ammo and currency from crates and defeated enemies. Early currency helps you unlock essential upgrades in the weapon shop.
Discover a hidden side quest typically near out-of-the-way areas. These early side quests often reward useful upgrades or cosmetic items.
Practice weapon swapping. Switching between your primary and special weapons is critical for dealing with enemy crowds and special armored foes.

During this stage you should aim to finish the main story beats while picking up at least a few High on Life collectibles and completing optional tasks. These extras give you a head start on upgrades and achievements.

Walkthrough Part 2: Mid-Game Strategies and Levels

Once you enter mid-game levels, mission complexity rises and new enemy types appear. Here are focused tips and a clear route:

Prioritize mobility upgrades — faster dodge, higher jumps, or reduced stun help you survive mixed enemy encounters.
Learn enemy patterns. Many mid-game foes have telegraphed attacks; recognizing them reduces damage taken and conserves healing items.
Balance your weapon loadout. Keep a crowd-control piece, a single-target high-damage weapon, and a utility gun with a unique effect for puzzle sections.

For each level, follow the mission markers but leave time to explore side paths. These often contain High on Life secrets like hidden lore logs or challenge rooms. If you want to pursue 100% completion, mark unreachable areas and return later with upgrades.

Weapons, Upgrades, and Build Tips

Weapons are characters in their own right. This section is a focused High on Life weapons guide to help you craft an effective build for your playstyle.

Weapon Types and Roles

Assault-style guns: reliable damage and good for general encounters.
Shotguns: ideal for close-range, high burst damage but less ammo-efficient.
Special/utility guns: these include slowing beams, explosive projectiles, or unique secondary effects that help with puzzles.

Upgrade Priorities

Ammo capacity — never underestimate the value of more ammo when exploring late-game levels.
Cooldown reduction for special abilities — faster access to special attacks changes how you approach fights.
Damage multipliers for your favorite weapon — invest, but not at the cost of survivability.

Tip: swap weapons mid-fight to exploit enemy weaknesses. If a boss is armored against bullets, switch to an elemental or explosive weapon. This is a core tactic for the tougher High on Life boss fights.

Side Quests, Collectibles, and the Map

Side content is where the game’s charm and extra rewards live. Follow these guidelines to maximize your gains from optional activities:

Track side quests on your map so you can return after unlocking key abilities; some quests require specific weapons or movement upgrades.
Collectibles fall into categories: story items, cosmetic unlocks, and achievement-related objects. Make a list when you first visit a level to avoid missing anything.
Use the map to identify secret alcoves and hidden passages. Some maps hide small icons indicating collectible clusters.

A helpful technique is to clear the main mission, then do a methodical sweep of the map for side quests and collectibles. This reduces backtracking and keeps momentum going between major story beats.

Boss Fights: Strategies for Major Encounters

Bosses are designed to be memorable and often require pattern recognition and equipment synergy. Use this checklist for any High on Life boss fights:

Study openings: bosses typically telegraph a heavy attack; dodge and counter during recovery windows.
Exploit elemental or mechanic weaknesses. If the boss summons adds, switch to area-of-effect weapons temporarily.
Manage your ammo: bring weapons that conserve ammo or carry an ammo regeneration upgrade if available.
Use the environment. Many boss arenas have destructible items or cover that can give you an advantage.

Example approach for a multi-phase boss: in phase one, focus on movement and dodging to learn attack patterns; in phase two, apply your heaviest sustained damage with cooldowns and assists; in phase three, conserve your last healing items and finish aggressively when the boss is staggered.

Puzzle Areas and Environmental Challenges

High on Life includes environmental puzzles that require timing, weapon abilities, or specific items. These puzzles slow the pace and add variety. How to handle them:

Observe first: before acting, look for patterns — moving platforms, timed doors, or enemy spawns tied to puzzle triggers.
Use the right gun: some puzzles require a specific firing mode or special weapon ability. If you can’t progress, swap to a ranged or utility weapon.
Patience: puzzle rooms often reward observation more than speed. If stuck, step back and consider whether skill upgrades are required.

When stuck, revisit earlier areas to ensure you didn’t miss a needed upgrade or collectible that unlocks a solution. This is a common theme across many High on Life levels.

Achievements, Secrets, and Completionist Tips

If you’re chasing 100% completion or specific High on Life achievements, follow these steps:

List required collectibles per level and mark them on the in-game map where possible.
Complete side quests as you go, but prioritize main story progression to unlock later areas that contain early-game secrets.
Replay levels to pick up missed items. The game allows revisits, and later upgrades often make previously tricky areas easy.
Search for hidden rooms: secret areas sometimes require precise jumps or shooting a hidden switch. Look for odd textures or suspicious decorations that hint at secret entrances.

Pro tip: Some achievements are time-sensitive or require specific choices. If an achievement doesn’t appear, consult the in-game journal to confirm progress and requirements.

Frequently Asked Questions (FAQ)

1. How long is a typical high on life walkthrough if I want to finish all side quests?

Completion time varies by playstyle, but expect 15 to 30+ hours for a thorough run with most side quests and collectibles. Speedruns and minimal-playthroughs will be shorter, but thorough exploration increases both enjoyment and rewards.

2. Which weapons should I upgrade first in High on Life?

Focus on ammo capacity, cooldown reduction, and one reliable primary weapon you enjoy using. Utility upgrades that improve mobility are also high-priority because movement often trumps raw damage in many encounters.

3. Are there any secret areas or collectibles I can miss permanently?

Most collectibles can be revisited, but some side quests may require specific choices or progressions. If you miss a timed or choice-based quest, consider reloading an earlier save or replaying the level later when it’s accessible.

4. What’s the best approach for mid-game boss fights?

Observe patterns, conserve ammo, and use environment and weapon synergies. Phase-based bosses reward patience: dodge heavy attacks, punish during recovery, and use area-of-effect weapons when the boss summons adds.

5. How do I find all the High on Life secrets and collectibles?

Use the map for indicators, search off-path areas, listen to NPC dialogue for clues, and return with upgrades to unlock previously unreachable spots. Systematically comb each level after completing main objectives to find most secrets.

Conclusion

This high on life walkthrough aims to be a practical, friendly companion that covers main missions, side quests, weapons, puzzles, and boss strategies. Use the weapon tips, map strategies, and checklist for collectibles to shape your playthrough. Remember: exploration and experimentation are part of the charm. Enjoy the humor, try odd combinations of weapons, and return to earlier areas with fresh upgrades to uncover every secret. Have fun and good luck on your run through the game!